Fig. 5 | Nature Communications

Fig. 5

From: Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding

Fig. 5

Structural and antigenic assessment of AD8 trimer with different stabilization designs. a 2D class averages from negative-stain EM analysis of AD8 SOSIP trimer and AD8 MD64 trimer, classified as closed native-like, open native-like, or non-native. Red boxes indicate examples of open native-like trimers. b ELISA-binding curves for bnAbs and non-nAbs against AD8 SOSIP and the AD8 MD64 trimer. ELISA antigens are labeled on top of the plots, and the antibodies are labeled in the legend. c SPR signal ratio for non-nAbs binding to AD8 MD64 trimers. The data are from one experiment and measurements are done in duplicate

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