Fig. 3
From: Systematic generation of biophysically detailed models for diverse cortical neuron types
Modeling narrower spike widths. a Voltage traces of an individual action potential from the experiment (black) and model fit using conductance set A (red); scale bar, 2 ms. The major currents flowing during the action potential are shown below; scale bar, 2 nA. b Voltage traces and currents during an individual action potential from the experiment (black) and model fit using conductance set B (blue); scale bar, 2 ms (horizontal), 2 nA (vertical). c Comparison of model and experimental action potential widths across all models. Red dots are models fit with conductance set A; blue dots are models fit with conductance set B. The darker dots represent cases when both types of fits were performed on the same cell, which was typically done at intermediate spike widths. d Voltage-clamp measurements of model currents in response to a range of holding potentials (–80 mV to +40 mV) from –90 mV. Currents that are from conductance set A are shown in red. Currents from the set B sodium conductance (left, scale bar: 2 nA vertical, 2 ms horizontal), M-type potassium conductance (middle, scale bar: 5 nA vertical, 50 ms horizontal), and slow potassium conductances (right, scale bar: 3 nA vertical, 500 ms horizontal) are shown in blue. Note that a single slow potassium current in set A was replaced by two potassium conductances in set B
