Fig. 8
From: Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
Hyperglycaemia causes changes in [U-13C]-glucose labelling. Percentage of label incorporation of the indicated metabolites in INS-1 cells cultured at 5 mM (white) or 25 mM (black) glucose and then challenged with 2 or 20 mM [U-13C]-glucose for 30 min. Label incorporation is defined as the proportion of molecules in a metabolite pool containing one or more 13C atoms. DHAP, dihydroxyacetone phosphate. PEP, phosphenolpyruvate. Data show mean ± s.e.m. (where from left to right for each metabolite, n = 13, 13, 19 and 18). One-way analysis of variance and Bonferroni-corrected Welch’s t test. *p < 0.05, **p < 0.01,***p < 0.001, nd not detected
