Fig. 1
From: FOXF2 reprograms breast cancer cells into bone metastasis seeds
Breast cancers with high FOXF2 expression have a propensity to metastasize to bone. a–b FOXF2 expression levels in the luminal and basal-like/triple-negative subtypes of human breast cancer were compared by chi-square tests. FOXF2 mRNA levels were mined from the GSE12777_GSE15026_GSE65194 data set of breast cancer cell lines (n = 95); a and the E-MTAB-365 (n = 287) and GSE3494 (n = 118) data sets of primary breast cancer tissues (b). The boxplots show the minimum, 25 percentile, median, 75 percentile, maximum, and outliers. c FOXF2 mRNA levels in primary breast cancer tissues that developed distant metastasis (n = 33) were detected by RT-qPCR. d FOXF2 mRNA levels in primary breast cancer tissues (n = 368) were mined from the GSE2034_GSE2603 data set. The Kaplan–Meier survival curve shows the BMFS status of patients in the FOXF2high and FOXF2low groups. The overall, luminal subtype and TNBC subtype cases were analyzed separately
