Fig. 8 | Nature Communications

Fig. 8

From: Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases

Fig. 8

Potential role of the proposed mechanisms in the renal cancer. a Difference of signaling of renal cell carcinoma, ACHN, related to EMT, cell–cell adhesion, cell migration between disseminated cells, and cells remaining within the monolayer after dissemination elicited by mechanical cues. b Analysis of patient data, sequenced tumors (451 samples) of renal clear cell carcinoma, (TCGA, provisional) via cbioportal. Oncoprints show alterations in YAP1 and WT1 across a set of kidney renal clear cell carcinoma. Z-scores for mRNA expression (RNA Seq V2RSEM) and protein expression were 2.326 for 99% confidentiality (one tail). c Disease-free survival Kaplan–Meier estimate of upregulated YAP1 (left) and YAP1/WT1 (right) (see details in the “Methods” section)

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