Fig. 1
From: Crystal structure of an adenovirus virus-associated RNA
Overall structure of Adenovirus 2 VA-I RNA. a Cartoon model of VA-I and PKR interactions. S: stem; L: loop. S1 and L2 were absent from the crystal construct. b Secondary structure of crystallized VA-I RNA. Tetrastem: green, Loop 8: violet, Loop 10: orange, engineered sequences: gray. Three single-stranded, helix-capping purines, A36, G106, and A123, are in red italics. Leontis–Westhof symbols74 denote non-canonical base pairs. Arrowheads denote chain connectivity. Dotted red lines indicate hydrogen bonds. G60 is disordered. c Inhibitory activities of wild-type and ΔTS (deletion of terminal stem; crystallization construct) VA-I. Several ΔTS RNAs showed an enhanced inhibitory activity than WT, as previously reported26. Error bars here and thereafter represent standard deviations (s.d.) from three independent replicates. d, e Two views of the overall structure of VA-I, colored as in b
