Fig. 7 | Nature Communications

Fig. 7

From: The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression

Fig. 7

Runx2 insufficiency mitigates OA phenotype in dKO mice. a Representative histology images of 9-month-old tKO (miR-204flox/flox; miR-211flox/flox; Runx2+/flox; Prx1-Cre) mice compared with dKO (miR-204flox/flox; miR-211flox/flox; Prx1-Cre) and control (miR-204flox/flox; miR-211flox/flox) mice. Yellow arrowheads, articular cartilage degradation; green arrowhead, synovial hyperplasia; black arrowhead, subchondral sclerosis. n = 5. Scale bars, 200 μm. b–d IHC results of Runx2 (b), Adamts5 (c), and MMP13 (d) expression in the control, dKO and tKO mice. Red arrowheads, Runx2-, Adamts5-, or MMP13-positive cells. Scale bar, 50 μm

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