Fig. 4
From: Accurate estimation of cell-type composition from gene expression data
Deconvolution estimates of bulk mouse ISC data across various conditions. The control condition corresponds to Lgr5-eGFP+ intestine cells 1.5 days post treatment with Ad-Fc, the loss of function (LOF) condition corresponds to Lgr5-eGFP+ intestine cells 1.5 days post treatment with Ad-LGR5-ECD, and the gain of function (GOF) condition corresponds to Lgr5-eGFP+ intestine cells 1.5 days post treatment with Ad-RSPO1. Each point corresponds to the deconvolution estimate of a cell type for a single bulk data set, for the dampened weighted least squares (DWLS), quadratic programming (QP), and ν-support vector regression (ν-SVR) deconvolution methods. Cell types include cycling and non-cycling intestinal stem cells (ISCs), transit amplifying (TA) cells, and various differentiated cell types. The center line of the boxplot corresponds to the median value, while bounds of the boxplot correspond to the 25th and 75th percentiles. The upper whisker bound corresponds to the smaller of the maximum value and the 75th percentile plus 1.5 interquartile ranges; the lower corresponds to the larger of the smallest value and the 25th percentile minus 1.5 interquartile ranges
