Fig. 2

Macroevolution from AAH to ADC at chromosomal level. a The somatic copy number aberrations across the genome. Each row represents all lesions grouped by histologic stage. Copy number gains, defined as the mean log2 ratio (IPN versus germ line DNA) >0.3 of all lesions by each given stage, are represented as red bars. Copy number losses, defined as the mean log2 ratio (IPN versus germ line DNA) ≤0.3 of all lesions by each histologic stage are represented as blue bars. The height of the bars is proportional to the fraction of IPNs showing copy number gains or losses at corresponding chromosomal regions. b The allelic imbalance. Each green dot represents the number of AI events in each IPN and the blue dots represent the mean number of AI events detected in IPNs of each histologic stage. The difference between all stages was assessed by Kruskal–Wallis H test