Fig. 4
From: Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma
Cancer gene mutations and copy number aberrations in IPNs. Cancer gene mutations were defined as nonsynonymous mutations in known cancer genes identical to those previously reported and frame-shift indels or truncating mutations in tumor suppressor genes. Cancer genes located in chromosomal segments with copy number gains (red) or losses (green) are shown. A threshold of log2 ratio (IPN versus germ line DNA) >2 or ≤2 was used to screen for chromosomal gains or losses, respectively
