Fig. 1
From: Structural basis of the activation of type 1 insulin-like growth factor receptor
Overall structure of the IGF1R-IGF1 complex. a 3D reconstruction of the IGF1R dimer with one IGF1 bound and the corresponding ribbon representation of this complex fitted into cryo-EM map. b The ribbon representation of IGF1R-IGF1 complex showing in two orthogonal views. c Cartoon representation of the IGF1R-IGF1 complex depicting the IGF1R dimer bound with one IGF1. The two IGF1R protomers are colored in green and blue, respectively; the IGF1 is colored in pink. The name of each ___domain is labeled as follows: L1 and L2 (leucine-rich repeat domains); CR (cysteine-rich ___domain); FnIII-1, FnIII-2 and FnIII-3 (fibronectin type III domains); α-CT (the C-terminus of the α-subunit)
