Fig. 4
From: Epigenetic modifiers DNMT3A and BCOR are recurrently mutated in CYLD cutaneous syndrome
UV signature analysis reveals distinct mutational mechanisms in skin and tracks origin of lung tumors. a Examples of intermittently sun-exposed and sun-protected CCS tumors demonstrate differing mutational profiles. Mutational signature analysis reveals UV-related signature 7 in sun-exposed tumors only. b In one patient with three pulmonary lesions, a phylogenetic analysis reveals 1848 mutations were shared in common and showed a UV signature. Hence, these benign pulmonary lesions had a common origin, likely sun-exposed skin
