Fig. 5
Transcriptome profiles in TNBC regulated by the CDK2/EZH2 axis. The xenograft tumors of SUM-149 cells were treated with vehicle, CDK2i and EZH2i, respectively. Total RNAs were isolated from the tumors by using RNeasy Mini Kit (Qiagen). Differential expression analyses of these tumors were performed by using Homo sapiens (GRCH37/hg19) as reference genome and genome annotation, and setting fold change to 2 and p < 0.05 as cutoff when using Limma package to call differential gene. a Venn diagram of the differential and commonly shared genes regulated by CDK2 and EZH2. b Representative heat map of top-regulated genes by blockade of CDK2/EZH2 signal axis. c Representative top-shared upregulation and downregulated genes and their involved pathways. Enrichment analysis was performed as described58. Source data are provided as a Source Data file.
