Fig. 1: Study design and analysis workflow.

Overview of study design to identify and characterise heart failure-associated risk loci and for secondary cross-trait genome-wide analyses. GWAS, genome-wide association study; QTL, quantitative trait locus; MAGMA, Multi-marker Analysis of GenoMic Annotation; SNP, single-nucleotide polymorphism; mtCOJO, multi-trait-based conditional and joint analysis.