Fig. 2: Manhattan plot of genome-wide heart failure associations.
The x-axis represents the genome in physical order; the y-axis shows −log10 P values for individual variant association with heart failure risk from the meta-analysis (n = 977,323). Suggestive associations at a significance level of P < 1 × 10−5 are indicated by the blue line, while genome-wide significance at P < 5 × 10−8 is indicated by the red line. Meta-analysis was performed using a fixed-effect inverse variance-weighted model. Independent genome-wide significant variants are annotated with the nearest gene(s).
