Table 1 Previously unreported loci associated with asthma in Iceland – UK biobank meta analyses.

From: Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis

Lead SNP

chr:Position

Allele (EA/OA)

EAF % (ICE/UK BB)

Gene

Coding effect

Coding change

OR (95% CI)

P

Phet

rs2230624a

chr1:12115601

A/G

1.2/1.5

TNFRSF8

Missense

Cys273Tyr/Cys162Tyr

0.82 (0.78–0.87)

8.3E-13

0.14

rs2228552a

chr1:31699894

T/G

68.3/64.3

COL16A1

Missense

Thr62Lys/Thr52Met

1.04 (1.02–1.05)

2.6E-08

0.86

rs2296618

chr1:198697103

G/A

14.4/13.5

PTPRCa

Downstream

−

0.94 (0.93–0.96)

6.9E-10

0.36

rs7626218a

chr3:177134250

T/A

41.1/39.5

TBL1XR1a

Intron

−

0.96 (0.95–0.97)

5.9E-11

0.14

rs34712979

chr4:105897896

A/G

24.4/25.8

NPNT

Splice region

−

1.04 (1.03–1.06)

3.9E-09

0.85

rs11746314a

chr5:157325949

G/A

3.6/5.8

CYFIP2a

Intron

−

1.09 (1.06–1.12)

2.1E-10

0.832

rs3813308

chr5:119355086

G/C

47.3/43.5

TNFAIP8

5 prime UTR

−

1.04 (1.03–1.06)

2.83E-11

0.8

rs1800797

chr7:22726602

G/A

52.2/58.0

IL6a

Upstream

−

1.04 (1.03–1.05)

2.9E-10

0.66

rs34173062

chr8:144103704

A/G

6.6/7.2

SHARPIN

Missense

Ser17Phe

1.08 (1.05–1.10)

1.0E-08

0.28

rs41283642a

chr9:99153605

T/C

1.9/3.4

TGFBR1

3 prime UTR

−

0.89 (0.86–0.83)

2.16E-10

0.05

rs12788104b

chr11:1129831

G/A

73.4/68.7

MUC2c

Intergenic

−

1.04 (1.03–1.06)

1.7E-10

0.09

rs174562a

chr11:61817672

G/A

38.8/34.6

FADS1c

Upstream

−

0.96 (0.95–0.97)

6.3E-11

0.31

rs7961712a

chr12:94211187

A/G

86.3/85.0

PLXNC1c

Intron

−

1.06 (1.04–1.08)

5.8E-11

0.45

rs34939984

chr16:27234391

T/C

40.1/35.9

NSMCE1c

Intron

−

1.04 (1.03–1.06)

5.2E-11

0.41

rs3024664

chr16:27360103

C/T

93.5/93.9

IL4Rc

Intron

−

1.12 (1.09–1.15)

4.4E-17

0.23

rs6498021

chr16:27403057

G/T

85.3/86.0

IL21R

Intron

−

0.95 (0.93–0.97)

2.8E-08

0.30

rs179771

chr16:27406423

C/G

53.9/48.8

IL21Rc

Intron

−

1.04 (1.03–1.05)

3.23E-09

0.08

rs117552144

chr19:3136093

T/C

5.3/6.7

GNA15

5 prime UTR

–

1.09 (1.06–1.11)

6.7E-10

0.74

rs8103278a

chr19:45867123

A/G

31.3/35.3

SYMPKc

Upstream

−

0.96 (0.95–0.97)

1.8E-10

0.84

  1. Results are shown for the combined sample-sets of Iceland and the UK BB. Phet represents the statistical heterogeneity between the two sample-sets. Gene indicates the most likely candidate gene at the locus as described in Supplementary Data 7
  2. EA effect allele, OA other allele, EAF effect allele frequency ICE Iceland, UK BB UK biobank, OR odds ratio
  3. a loci reported in Johansson et al15. while this paper was in review
  4. b loci reported in Shrine et al14. while this paper was in review
  5. cThe closest gene is indicated for loci where our analysis do not pinpoint the most likely gene candidate
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