Fig. 1: Regulatory variants within the FAM13A locus are associated with several IR traits.
From: FAM13A affects body fat distribution and adipocyte function
Intronic non-coding variants in the FAM13A locus show associations with several IR-related and metabolic traits, including body fat percentage (a), and fasting insulin (b) and waist-hip ratio (c) (adjusted for BMI) across cohorts and studies. These GWAS association signals colocalize with FAM13A eQTL association signal in subcutaneous adipose tissue (from GTEx v7, d). However, this association is not robust in visceral adipose tissue (e). f The variants show evidence of enrichment in a regulatory active H3K27ac region in adipose nuclei. Annotations from pancreas and lung are shown as negative comparators.
