Fig. 6: Diagnostic performance of the genetic risk score (GRS) and the combined risk score (CRS).

Genetic effects expressed as odds ratios (OR) and 95% confidence intervals in reference to the lowest decile of the GRS distribution for a East Asian discovery, b European discovery, and c European validation cohorts combined. GRS and CRS Receiver Operating Characteristics (ROC) curves for d East Asian discovery, e European discovery, and f European validation cohorts combined; AUROC Area under the ROC curve. Distributions of the CRS between healthy controls, diseased controls, and MN cases for g East Asian discovery, h European discovery, and i European validation cohorts combined. The box plots depict medians (horizontal lines), interquartile ranges (boxes), and minimum/maximum values (whiskers). The discovery CRS cut-offs of 1.00 and 1.45 in East Asians and 2.05 and 2.72 in Europeans have 97% and 99% specificity, respectively. The same European cut-offs were applied to the validation cohorts for comparisons of specificity and sensitivity.