Fig. 1: Study design and genomic landscape.
From: The genomic and epigenomic evolutionary history of papillary renal cell carcinomas
a A schematic illustration of the dissection of multiple tumor samples from the center of the tumor towards the tumor’s periphery, plus metastatic samples in the adrenal gland as well as normal samples. For the analysis, the normal sample more distant from the tumor and with absence of tumor nuclei was chosen as reference. b Summary of subjects and samples that underwent different analyses based on DNA availability: whole-genome sequencing (124 samples from 29 subjects), deep targeted sequencing of cancer driver genes (139 samples from 38 subjects), genome-wide methylation (139 samples from 28 subjects) or SNP array profiling (only tumor samples, 101 samples from 38 subjects). c Tumor genomic alterations across histological subtypes. Shown are genome level changes, such as mutational burden, numbers of structural variants (SV) and retrotransposition events (TE), as well as other genomic alterations (denoted by different colors).
