Fig. 1: ARS2 is highly expressed in high-grade brain tumors. | Nature Communications

Fig. 1: ARS2 is highly expressed in high-grade brain tumors.

From: ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages

Fig. 1

a ARS2 expression in each type of brain tumor from the REMBRANDT database. b, c Kaplan–Meier survival plots for all glioma patients and GBM patients with high and low ARS2 expression. Data were obtained from the REMBRANDT of the National Cancer Institute (log-rank test). d, e Kaplan–Meier survival plots for all glioma patients and GBM patients with high (top 50% contribution) and low (down 50% contribution) ARS2 expression. Data were obtained from the TCGA database. f Immunoblot (IB) analysis of ARS2 in patient tissues from the National Cancer Center, Republic of Korea. GAPDH was used as a loading control45. g Representative immunofluorescence (IF) image of ARS2 and Nestin expression in GBM xenografts derived from X01 cells. Nuclei were counterstained with DAPI (blue). Scale bar, 50 μm. h Percentage of ARS2-positive cells among Nestin-positive and -negative cells. Lines show means and ±SD. i Correlation dot-plot of ARS2 and Nestin from the TCGA database (n = 162).

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