Fig. 1: Biologically active compounds and drugs derived from chiral carboxylic acid.
From: Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids
Ibuprofen and Naproxen (nonsteroidal anti-inflammatory drugs); (R)-Tiagabine (γ-aminobutyric acid reuptake inhibitor); Artemisinin (antimalarial drug); Rupintrivir (rhinovirus protease inhibitor); (S)-Equol (soy isoflavonoid metabolite); Sacubitril (antihypertensive drug used in combination with Valsartan).
