Fig. 8: Theophylline accelerates and enhances PNS remyelination and functional recovery.
From: EEF1A1 deacetylation enables transcriptional activation of remyelination
a, c Electron micrographs of Cr ultrathin sections at 14dpl, 30dpl (a) and 2mpl (c) from mice treated with theophylline or vehicle at 10dpl for 4 days, and myelin thickness quantification (g ratio) of remyelinated axons (n = 3 animals per group per time-point, 14dpl: p = 0.000046, 30dpl: p = 0.048585, 2mpl: pVehicle/No-lesion=0.013591, pTheo/No-lesion=0.076193, pTheo/Vehicle=0.034469). b Quantification of motor (Rotarod) and sensory (toe pinch) function recovery at 14 and 30dpl in theophylline- and vehicle-treated mice (4-day treatment at 10dpl). 14dpl: n = 9–10, pRotarod=0.02518, pToe-pinch=0.002327, 30dpl: n = 6 per group, pRotarod = 0.489629, pToe-pinch=0.000363. Data are presented as mean values ± SEM. Unpaired one-tailed (gray asterisks) or two-tailed (black asterisks) student’s t-tests. Scale bars: 5 µm (a, b), 10 µm (c). Source data are provided as a Source Data file.
