Fig. 2: Non-silent mutations in commonly mutated genes and altered pathways in colorectal tumors. | Nature Communications

Fig. 2: Non-silent mutations in commonly mutated genes and altered pathways in colorectal tumors.

From: Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival

Fig. 2

a The top 50 mutated genes in non-hypermutated and hypermutated tumors are shown. Significantly mutated genes identified by MutSigCV (q < 0.1) are indicated with asterisks. b Oncoprint display of alterations in main signaling pathways in non-hypermutated and hypermutated tumors. Contributions of individual genes to pathways are shown in Supplementary Fig. 2. Chi-square test p-values show significant differences in mutated pathways between non-hypermutated and hypermutated tumors. c Frequencies of mutated genes in pathways in non-hypermutated (NHM) and hypermutated (HM) tumors are shown. Chi-square test p-values compare mutation frequencies of genes with non-silent mutations between non-hypermutated and hypermutated tumors.

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