Fig. 3: Profiling of colorectal tumors with CTNNB1 missense mutations and in-frame indels. | Nature Communications

Fig. 3: Profiling of colorectal tumors with CTNNB1 missense mutations and in-frame indels.

From: Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival

Fig. 3

a CTNNB1 hot spot mutations affecting codons D32 to S45 are enriched in tumors without APC truncations within the first 1600 codons. The CTNNB1 hotspot mutations are frequent in tumors with MSI. b The number of tumors mutated in the mutation hotspot region of CTNNB1. S33, S37, T41, and S45 are the sites of phosphorylation by kinase.

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