Fig. 1: Pipeline overview. | Nature Communications

Fig. 1: Pipeline overview.

From: Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease

Fig. 1

Large-scale, high-dimensional datasets generated in hundreds of subjects serve as the input into our integrative pipeline (a), which comprises a series of steps that first generate the appropriate input features for causal network reconstructions (b, c), then network reconstruction and identification of key driver genes (d), and finally validation via three independent paths: replication (e), human genetic association (f), and experimental disease model (g).

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