Fig. 4: Genome plot and mutational signature landscape of all four patients included in this study.
From: Accelerated single cell seeding in relapsed multiple myeloma
The plots in the top row (a–d) show all the genomic events and mutational signatures shared by all samples in each patient (i.e., events in the trunk of the phylogenetic tree). The plots on the bottom row (e–h) show the events and mutational signatures not shared by all samples in each patient (i.e., events in the branches of the phylogenetic tree). Copy number aberrations are annotated in the periphery of the circos plots (blue = gain; red = loss of heterozygosity). Structural variants are reported within the circle (black = translocations; blue = inversions; green = tandem-duplications; red = deletions). The asterisks in the barplots reflect the presence of transcriptional strand bias for SBS-MM1 (melphalan-associated signature). Samples I-H-130718 and I-H-130720 were taken from the patients with short survival. Confidence interval of each mutational signature was generated by drawing 1000 mutational profiles from the multinomial distribution, each time repeating the signature fitting procedure, and finally taking the 2.5th and 97.5th percentile for each signature.
