Fig. 8: Early versus late divergence of disease sites.
From: Accelerated single cell seeding in relapsed multiple myeloma
a SBS1 is a mutational signature reflective of biological cell aging. By estimating changes in SBS1 in the trunk and the branches, we were able to study the speed of the tumor evolution in a given site at a given time-point. Here, we show the difference in SBS1 branch:trunk ratio between newly diagnosed and relapsed multiple myeloma (p-value estimated using Wilcoxon tests). A lower SBS1 branch:trunk ratio represents a highly accelerated evolution since divergence from the trunk (the most recent common ancestor). Boxplots show the median and interquartile range; observations outside this interval are shown as dots. b A schema summarizing the seeding patterns over time, starting as slow seeding and tumor growth during the precursor phase, with acceleration in advanced disease.
