Fig. 2: The overall cryo-EM structure of PACAP27–VIP1R–Gs complex.

a A cut-through view of the cryo-EM map of PACAP27–VIP1R–Gs complex with a disc-shaped micelle. b A cartoon representation of the PACAP27–VIP1R–Gs complex. c Extracellular view of the PACAP27–VIP1R–Gs complex structure. PACAP27 is colored in orange; VIP1R in green; Gαs Ras-like ___domain in yellow; Gβ subunit in blue; Gγ subunit in purple; Nb35 in gray; and lipid molecules in cyan.