Fig. 1: Acute lung injury (ALI) increases AAA development. | Nature Communications

Fig. 1: Acute lung injury (ALI) increases AAA development.

From: Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages

Fig. 1

(a) Retrospective analysis of clinical cohort representing the prevalence of COPD in patients diagnosed with AAA. n = 632. Aneurysm incidence (b) and severity (c) of ALI mice treated with Ang II and compared to Ang II alone. n = 5 per group. (d) Photomicrographs of aortas, (e) representative color Doppler ultrasound images of aortic flow and M-mode pictures of mice as indicated. Dotted lines delineate the aortic wall. Arrows show diameter. Chronological quantifications of maximal aortic diameter (f) and at day 28 (g). n = 5 per group. *P < 0.05. (h) Representative images of Verhoeff-Van Gieson staining of elastin in murine aortic section as indicated. Arrows point to elastin breaks (scale bar = 50 µm). (i) Fluorescence staining and quantification of macrophages (CD68) in aortic sections as indicated. AU, Arbitrary units (scale bar = 200 µm). n = 3 per group. **P = 0.0049. Data is presented as mean, error bars represent s.e.m. P values were calculated using two-tailed unpaired Student’s t-tests.

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