Fig. 8: Schematic representation of our main findings. | Nature Communications

Fig. 8: Schematic representation of our main findings.

From: Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages

Fig. 8

HMGB1 derived from injured lungs is captured by TLR4 transmural macrophages in the abdominal aorta. Activation of TLR4 by HMGB1 upregulates RIPK3 and activates its phosphorylation. RIPK3 activates phospho-DRP1 which triggers mitochondrial fission and increases mitochondrial reactive oxygen species (ROS) production. ROS stimulates the expression of MMP12 by macrophages responsible for elastin fiber degradation in the aorta. Inhibition of phosphorylation of RIPK3 on Serine 204 refrains DRP1 activation and subsequent MMP12 expression.

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