Fig. 3: Comparison on genomic alterations between our patients and TCGA patients. | Nature Communications

Fig. 3: Comparison on genomic alterations between our patients and TCGA patients.

From: Genomic and transcriptomic alterations associated with drug vulnerabilities and prognosis in adenocarcinoma at the gastroesophageal junction

Fig. 3

a Correlations of arm level CNV frequencies between our tumor samples and TCGA samples. Red and blue represent arm level gain and loss, respectively. b Bar plots comparing log2-tranformed GISTIC G-scores, a measure for both frequency and amplitude, of focal copy-number gain (upper panel) and loss (lower panel) regions in our tumor samples and TCGA samples. c Shared and unique putative CNV driver genes targeted by recurrent focal copy-number gains (upper panel) and losses (lower panel) in our samples and TCGA samples. d Bar plots comparing amplification (red) and deletion (blue) frequencies of putative CNV driver genes (c) across two cohorts. Genes with significantly different alteration frequencies in two cohorts (P < 0.05) were asterisked. e Bar plots comparing the frequencies of featured pathway perturbations across two cohorts. Dashed lines indicate 10% alteration frequency.

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