Fig. 2: Comparison of human and mouse GITR–GITRL interfaces.
From: Structures of mouse and human GITR–GITRL complexes reveal unique TNF superfamily interactions
a Human and mouse GITR interact similarly with their cognate receptors (GITR shown in blue, GITRL in orange). Close view of 1:1 ligand–receptor interfaces are shown for human cartoon (b) and electrostatic surface (c) and mouse cartoon (d) and electrostatic surface (e). While having similar overall structure, the interfaces have low sequence conservation, with steric and electrostatic differences.
