Fig. 6: Inhibition of SuM neurons disrupts reward seeking, but not consumption. | Nature Communications

Fig. 6: Inhibition of SuM neurons disrupts reward seeking, but not consumption.

From: Supramammillary neurons projecting to the septum regulate dopamine and motivation for environmental interaction in mice

Fig. 6

a Diagram showing operant sucrose-seeking procedure with cue discrimination. b SuM cannulation for muscimol + baclofen infusions. Left: Schematic showing a guide cannula targeting the SuM. Middle: Darkfield histological example showing SuM guide-cannula track with injection-cannula track outlined in dotted yellow line; scale bar = 500 µm. Right: Diagram showing coronal sections with the placements of cannulae. c–i Performance measures during the operant sucrose-seeking task. *p < 0.05, **p < 0.01, ***p < 0.001, paired t-test (n = 5 mice). j Schematic of mouse operant-conditioning chamber with two levers retracted. k–m Performance measures during the sucrose drinking test. **p < 0.01, paired t-test (n = 7 mice). n Here, 5 min sucrose intake over the course of the 30 min test are shown (mean ± SEM, n = 6). Source data are provided as a Source Data file.

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