Fig. 6: Characterization of FYN-TRAF3IP2-driven lymphomas in mice.

a Gating strategy for T_fh cells on lymph node cell suspensions from mice with empty-vector-transduced cells (top). Representative flow cytometry plot for the immunophenotype of FYN-TRAF3IP2-driven lymphomas (bottom, n = 9). b Histograms for BCL6 protein in T_fh cells (representative for n = 2), sorted viable CD4⁺GFP⁺ splenocytes from FYN-TRAF3IP2-driven lymphomas (n = 5) and PD-1⁻CXCR5⁻ CD4⁺ T cells (representative for n = 2). Representative flow cytometry plots (left) and quantification (right) of CD19⁺B220⁺ B cells (c), CD95⁺GL7⁺ germinal center (GC) B cells (gated on CD19⁺B220⁺ B cells) (d) and CD19^lo-intB220^lo-intCD138⁺ plasma cells (e) in lymph node suspensions from mice transplanted with empty-vector-transduced (EV) cells, FYN-TRAF3IP2-transduced (FT) cells or FYN^G2A-TRAF3IP2-transduced cells (F^G2AT). n = 5 mice per group. p values were calculated with Tukey’s post-hoc multiple comparisons test. f Representative pictures of CD31 immunohistochemistry on lymph node sections of mice transplanted with HSPC transduced with empty pMIG vector, pMIG-FYN-TRAF3IP2 or pMIG-FYN^G2A-TRAF3IP2. n = 5 mice per group. Scalebars represent 50 µm. Data are represented as mean ± SD.