Fig. 1: PD-L1, TMB, and global RNA-seq profiles in mUC, NSCLC, and RCC cohorts.
From: Molecular determinants of response to PD-L1 blockade across tumor types
a Bar chart representing the distribution of PD-L1 expression on TC and IC by indication and response group. PD-L1 distribution between response groups within and across indications was statistically tested using the two-sided Pearson’s chi-squared test. b Boxplot representing TMB by indication and response group. TMB differences within each indication were tested using the non-corrected two-sided Wilcoxon rank-sum test. The center of the boxplot represents the median. The lower and upper hinges correspond to the first and third quartiles. The upper whisker extends from the hinge to the largest value no further than 1.5 × IQR (interquartile range) from the hinge. The lower whisker extends from the hinge to the smallest value at most 1.5 × IQR of the hinge. c Venn diagram representing the overlap between responders, PD-L1+ patients and TMBhigh patients. d Two-dimensional scatter plot representing sample distribution according to the first two components obtained from principal component analysis (PCA) of the complete RNA-seq-evaluable dataset (n = 366) based on the 16,581 genes used for analysis. Dots are colored by indication and ellipses capture all samples within one standard deviation of the mean per normal probability statistics (68%). e Same as d, colored by response group.
