Fig. 3: Transcriptional correlates of response to PD-L1 blockade across indications.
From: Molecular determinants of response to PD-L1 blockade across tumor types
a In all tumors combined. Upper panel, Forest plot representing the pathway activity of WGCNA modules significantly enriched by Q-Gen analysis between responders and nonresponders across the combined cohorts or on an individual cohort basis. The pathway-level model contrasts responders and nonresponders, including indication as a covariate in the cross-indication analysis. The 20 modules detected as significant (p < 0.05) in any of the four models conducted are included in the display. Modules are ordered from left to right according to pathway activity across indications. Error bars represent the 95% confidence interval. Lower panel, heatmap representing per-indication pathway activity for modules selected from the combined cross-indication and per-indication analyses. Module enrichment significance is highlighted as a red dot (FDR-corrected p < 0.05) or a black dot (nominal p < 0.05). n = 208 mUC, n = 81 NSCLC, and n = 77 RCC biologically independent samples were examined. b Same as a for PD-L1+ (upper heatmap) and PD-L1− (lower heatmap) tumors separately.
