Fig. 1: Overview of PDOX and cell line establishment, characterization and preclinical testing, and pHGG data available in Pediatric Brain Tumor Portal. | Nature Communications

Fig. 1: Overview of PDOX and cell line establishment, characterization and preclinical testing, and pHGG data available in Pediatric Brain Tumor Portal.

From: Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma

Fig. 1

Patient high-grade glioma samples were directly implanted into recipient mouse brain and passaged as PDOX models. Cell lines were also established from a subset of PDOX models (left). Each PDOX or cell line, and when available, matched patient tumor, were evaluated for histopathology, DNA methylome profiles, genome-wide sequencing and RNAseq. Genome sequencing of matched normal reference is also available for most PDOX models. Chemical sensitivity testing was performed with cell lines (right). All associated data is available through an interactive data portal, the Pediatric Brain Tumor Portal (pbtp.stjude.cloud).

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