Fig. 2: DNA methylation classification of patient tumors is conserved in corresponding PDOXs and cell lines. | Nature Communications

Fig. 2: DNA methylation classification of patient tumors is conserved in corresponding PDOXs and cell lines.

From: Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma

Fig. 2

a t-SNE plot showing tumor subgroups based on DNA methylation profiling. Nineteen patient tumors (circles), 21 PDOXs (squares), and 14 cell lines (diamonds) are outlined in black. Lines connect PDOXs and cell lines with the patient tumors from which they were derived. Tumor subgroup classifications are color-coded. Circles without outlines are reference samples from Capper et al. Dashed square shows region containing all HGG samples. Classifications: Embryonal tumors: atypical teratoid rhabdoid tumors (ATRT), embryonal tumor with multilayered rosettes (ETMR), high-grade neuroepithelial tumor with BCOR alteration (HGNET_BCOR), and medulloblastoma (MB). Ependymal tumors: ependymoma (EPN), subependymoma (SUBPEN), myxopapillary ependymoma (MPE), posterior fossa (PF), supratentorial (ST). Glioblastoma: diffuse midline glioma (DMG) and glioblastoma (GBM). Other glioma: anaplastic pilocytic astrocytoma (ANA_PA), high-grade neuroepithelial tumor with MN1 alteration (HGNET_MN1), anaplastic pleomorphic xanthoastrocytoma (PXA). Control tissue, inflammatory tumor microenvironment (CONTR_INFLAM). b Enlarged view of boxed region in a. Dashed oval shows patient tumors with MMRD and derived PDOX models.

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