Fig. 4: Genomic landscapes of PDOX and cell lines conserve alterations present in the matched patient tumor and represent a variety of pHGG subtypes. | Nature Communications

Fig. 4: Genomic landscapes of PDOX and cell lines conserve alterations present in the matched patient tumor and represent a variety of pHGG subtypes.

From: Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma

Fig. 4

Alterations in genes recurrently mutated in pHGG are indicated on the left. Pathways are indicated on the right. Columns show tumor samples. PDOX and cell lines are grouped together with patient tumors from which they were derived. Numbers are the PDOX identifier IDs across the top, sequence file IDs across the bottom. Rows show the ___location of patient tumors, DNA methylome classification, and tumor sample type. In some cases, patient tumor samples from recurrence or autopsy are included along with the diagnostic sample. Asterisk in tumor sample type indicates the patient tumor from which the PDOX was derived. For 7, passages 7 and 10 of SJ-DIPGX7 are shown, and for 29, passages 3 and 4 of SJ-DIPGX29 are shown. PDOX* (dark gray box) indicates xenograft generated by implanting the associated cell line. Mutations in signature genes shown as rows are indicated by Mutation Type color code. G in block indicates germline mutation.

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