Fig. 1: Overview of EWASplus approach. | Nature Communications

Fig. 1: Overview of EWASplus approach.

From: A machine learning approach to brain epigenetic analysis reveals kinases associated with Alzheimer’s disease

Fig. 1

The EWASplus procedure is composed of four major steps: (1) Training data collection from existing EWASs; (2) External feature (from sources such as ENCODE and Roadmap Epigenome consortia) selection; (3) Ensemble learning; and (4) Genome-wide CpGs risk prediction, in which trained ensemble learning model is applied genome-wide to score all CpGs.

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