Fig. 4: Histone marks associate with DNA replication timing.
From: The genetic architecture of DNA replication timing in human pluripotent stem cells
a Association of rtQTL genotypes with individual (left panel) or combinations (right panel) of histone marks. Positive (negative) values indicate that individuals with early (late)-replicating genotypes are more likely to carry a histone mark at those rtQTL sites. Right panel: while individual H3 methylation marks associate with late replication, the H3K4me3-H3K9me3-H3K36me3 combination is strongly associated with early replication, and even more so when combined with H3K56ac. Note the different Y scale. b Examples of rtQTLs associated with histone mark variations. Replication timing and corresponding histone ChIP-seq tracks for individual cell lines homozygous for the early- or late-replicating alleles. Early replication correlates with the presence of the specified histone marks.
