Fig. 5: Efficacy-safety profiles of anticoagulants (without DAPT) in porcine models.
From: Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors
Efficacy and safety were determined using ex vivo stent thrombosis and superficial ear vein bleeding models, respectively. a Representative photographs showing thrombi formed on coronary stents and endothelium-denuded pig aorta strips in pigs administered with saline (i.v. bolus, n = 7), 1 mg/kg variegin (i.v. bolus, n = 4), 0.25 mg/kg ultravariegin (i.v. bolus, n = 3), 100 u/kg UFH (i.v. bolus, n = 5) and 0.75 mg/kg (i.v. bolus) plus 1.75 mg/kg/h (i.v. continuous infusion) bivalirudin (n = 3). Experiments were repeated in the indicated number of animals independently with similar results. b Total weight of thrombi (one-way ANOVA P < 0.0001). c Bleeding time (one-way ANOVA P = 0.0474). Multiplicity-adjusted P values for post hoc Tukey’s multiple comparisons between respective anticoagulants with saline were indicated immediately above each treatment. Multiple comparisons among anticoagulants were indicated on top of the plot. Data shown are mean ± SD.
