Fig. 6: Efficacy-safety profiles of anticoagulants (with DAPT) in porcine models.
From: Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors
Efficacy and safety were determined using ex vivo stent thrombosis and superficial ear vein bleeding models, respectively. All pigs were administered 300 mg aspirin and 180 mg ticagrelor orally (DAPT regimen) 16 h prior to the experiments. a Representative photographs showing thrombi formed on coronary stents and endothelium-denuded pig aorta strips in pigs administered with DAPT only (n = 13), DAPT with 0.1 mg/kg variegin (i.v. bolus, n = 5), DAPT with 0.025 mg/kg ultravariegin (i.v. bolus, n = 3), DAPT with 100 u/kg UFH (i.v. bolus, n = 4), and DAPT with 0.75 mg/kg (i.v. bolus) plus 1.75 mg/kg/h (i.v. continuous infusion) bivalirudin (n = 4). Photograph from a pig receiving saline without DAPT, as depicted in Fig. 5a, is reproduced here for comparison. Experiments were repeated the indicated n number of animals independently with similar results. b Total weight of thrombi (one-way ANOVA P = 0.0007). c Bleeding time (one-way ANOVA P < 0.0001). Multiplicity-adjusted P values for post hoc Tukey’s multiple comparisons between respective anticoagulants with DAPT are indicated immediately above each treatment. Multiple comparison among anticoagulants were indicated on top of the plot. Data shown are mean ± SD.
