Fig. 8: Model for biogenesis and function of regular nucleosome arrays. | Nature Communications

Fig. 8: Model for biogenesis and function of regular nucleosome arrays.

From: The biogenesis and function of nucleosome arrays

Fig. 8

Transcription is strongly disruptive to nucleosome arrays and it takes ISWI-, Chd1- and/or INO80- remodelers to reinstate array architecture. Proper histone density is indispensable for spacing as neither DNA sequence-based nucleosome positioning nor the clamping activity of remodelers suffices. Remodelers also position the +1 nucleosome, thereby sharpening the site of transcription initiation (green arrows). Regularly spaced nucleosome arrays prevent cryptic transcription (red arrows), DNA damage, ectopic recombination and transposon integration within the gene body.

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