Fig. 6: Evaluation of the potential toxicity of ch128.1/IgG1 to committed hematopoietic progenitor cells. | Nature Communications

Fig. 6: Evaluation of the potential toxicity of ch128.1/IgG1 to committed hematopoietic progenitor cells.

From: Host receptor-targeted therapeutic approach to counter pathogenic New World mammarenavirus infections

Fig. 6

Human BMMC were treated with ch128.1/IgG1 at various concentrations and cultured for 14 days. Colony number data represent the mean ± standard error of quadruplicate samples. The data are representative of three separate experiments using BMMC from three different donors (data from donors two and three are shown in Supplementary Fig. 1). Statistical significance based on comparison to buffer alone treatment was determined using the nonparametric, unpaired Mann–Whitney test and the False Discovery Rate (FDR) approach with two-stage linear step-up method of Benjamini, Krieger, and Yekutieli was applied to account for multiple comparisons. Colony forming unit-erythroid (CFU-E), burst forming unit-erythroid (BFU-E), colony forming unit granulocyte/macrophage (CFU-GM), colony forming unit granulocyte/erythroid/macrophage/megakaryocyte (CFU-GEMM). Source data are included in the Source Data file.

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