Fig. 2: A graphical representation of all pQTL discoveries in the current study.
From: Coding and regulatory variants are associated with serum protein levels and disease
The Manhattan plot in the top panel uses precise two-sided P-values as −log(P-value) for the association (linear regression) of low-frequency and common exome array variants to 4782 proteins in serum. The bottom panel shows the genomic locations of all study-wide significant pQTLs (linear regression, P < 1.92 × 10−10, two-sided), also shown in Supplementary Data 1, where the start position of the protein-encoding gene is shown on the y-axis and the ___location of the pSNP at the x-axis. Cis acting effects, using a 300 kb window, appear at the diagonal while trans acting pQTL effects including trans hot spots show up off-diagonally. The genetic loci highlighted across the x-axis are trans-acting hotspots.
