Fig. 5: Unannotated 3’UTR predictions across 39 GTEx tissues.
From: Leveraging omic features with F3UTER enables identification of unannotated 3’UTRs for synaptic genes
a Number of unannotated 3’UTRs predicted by F3UTER. b Total genomic space of unannotated 3’UTRs. The predictions are grouped and colour-coded based on their prediction probability score from F3UTER. c Number of genes associated with unannotated 3’UTRs, grouped by the type of gene association. In each barplot, tissues are sorted in descending order of the values plotted on the y-axis. The square boxes below the bars are colour-coded to group the tissues according to their physiology. d Violin plot comparing the RBP-binding density across known 3’UTRs (n = 14,924), predicted 3’UTRs (n = 7162), predicted non-3’UTRs (n = 57,688) and negative control (di-nucleotide shuffled sequences of predicted 3’UTRs, n = 6877). Only regions with RBP enrichment score greater than zero were displayed. Box plots show the median value (middle line), 25th and 75th percentile (box), and 1.5 times the interquartile range (whiskers). e Density distributions comparing the “constrained non-conserved” (CNC) scores between known (n = 15,279) and predicted 3’UTRs (n = 6522). p: p value of comparison calculated using two-sided Wilcoxon rank-sum test; es: Wilcoxon effect size (r).
