Fig. 1: Crystal structure of the HIF-3α-ARNT heterodimer in apo form.
From: Identification of oleoylethanolamide as an endogenous ligand for HIF-3α
a Schematic representation showing the ___domain arrangements of ARNT and HIF-3α. bHLH basic helix-loop-helix, PAS PER-ARNT-SIM, ODDD oxygen-dependent degradation ___domain, TAD transactivation ___domain, LZIP leucine zipper. b Overall structure of the HIF-3α-ARNT heterodimer in two views with all domains labelled. HIF-3α and ARNT are colored in orange and green, respectively. c Structure superimposition of HIF-3α-ARNT and HIF-2α-ARNT. d The shape of empty PAS-B cavities of HIF-3α (orange) and HIF-2α (magenta) shown in mesh.
