Fig. 4: Synapse subtypes with rapid protein turnover are preferentially affected in the Pax6+/− brain. | Nature Communications

Fig. 4: Synapse subtypes with rapid protein turnover are preferentially affected in the Pax6+/− brain.

From: Developmental disruption and restoration of brain synaptome architecture in the murine Pax6 neurodevelopmental disease model

Fig. 4

A Changes in synapse diversity in brain subregions between Pax6+/− and control mice for the different age groups. Scale bar (Cohen’s d) indicates increase in red and decrease in blue (P < 0.05, Bayesian test with Benjamini–Hochberg correction) of synapse diversity in Pax6+/− brain subregions. Absence of color indicates subregions where no significant differences occurred. B Ranking of PSD95-expressing synapse subtypes according to the number of brain regions affected in Pax6+/− mice. For each subtype the total number of brain subregions that showed a significant difference (P < 0.05, Bayesian test with Benjamini–Hochberg correction) in density between control and Pax6+/− mice was counted at all ages. Note skewing in SPL and LPL subtypes. Source data are provided as a Source Data file. C Quantification of the relative effect of the Pax6+/− mutation on SPL and LPL synapses. Red indicates a greater effect on SPL synapses and blue indicates a greater effect on LPL synapses. Scale bar, Cohen’s d; P < 0.05, Bayesian test with Benjamini-Hochberg correction. For brain region abbreviations (A, C) see Supplementary Data 1.

Back to article page