Table 2 Effect estimates for 20 genome-wide significant loci for IgA levels by trans-ancestry meta-analysis

RUNX3

1

25291697

rs188468174

C

0.876

3.42E−92

1.37E−91

0.0

0.55

Known

TNFSF4, TNFSF18

1

173163568

rs7518129

G

0.056

1.06E−16

4.24E−16

3.3

0.42

Known

GPATCH2

1

217563106

rs73100295

T

0.356

3.91E−08

3.11E−08

0.0

0.98

New

IL1R1

2

102689031

rs13427957

C

0.040

6.19E−10

3.86E−10

33.3

0.08

New

ELL2

5

95277555

rs3777175

G

0.084

7.81E−30

3.13E−29

0.0

0.50

Known

ANKRD55, IL6ST

5

55438580

rs6859219

C

0.073

1.41E−20

4.38E−20

12.4

0.31

Known

HLA

6

31106893

rs1265094

A

0.076

1.86E−31

7.43E−31

37.4

0.06

Known

RUNX2

6

45526470

rs1200427

T

0.059

6.85E−14

2.24E−13

20.1

0.23

New

CITED2

6

139975943

rs17069163

T

0.050

5.94E−11

2.01E−10

37.3

0.06

New

ZP3, SSC4D

7

76034150

rs55722505

C

0.048

8.61E−14

3.44E−13

23.6

0.18

New

TNFSF8, TNFSF15

9

117692882

rs3181356

T

0.069

1.13E−18

2.67E−18

0.0

0.75

Known

TMEM258, FADS2

11

61595564

rs968567

T

0.116

2.42E−41

3.05E−41

14.9

0.29

Known

OVOL1, RELA

11

65555524

rs10896045

A

0.066

2.57E−22

1.03E−21

0.0

0.84

New

POU2AF1

11

111267394

rs4938518

T

0.056

7.01E−16

2.80E−15

0.0

0.74

New

HDAC7

12

48214825

rs7487637

G

0.054

9.97E−15

3.99E−14

4.2

0.41

New

SH2B3

12

111833788

rs10774624

G

0.050

1.37E−13

3.25E−13

0.0

0.54

Known

TRAF3

14

103239630

rs12147883

C

0.048

5.42E−14

3.51E−14

8.4

0.35

New

LITAF

16

11717832

rs113962704

T

0.054

1.91E−12

6.02E−12

0.0

0.54

New

CTF1

16

30916129

rs1458201

A

0.052

2.02E−11

8.07E−11

25.1

0.16

New

HORMAD2, LIF

22

30448399

rs193473

A

0.067

1.58E−20

6.30E−20

0.0

0.51

Known